Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage

Blain, Emma Jane ORCID: https://orcid.org/0000-0001-8944-4254, Ali, Ahmed Yasine and Duance, Victor Colin ORCID: https://orcid.org/0000-0002-7555-2016 2010. Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytotherapy Research 24 (6) , pp. 905-912. 10.1002/ptr.3055

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Abstract

The aim of this study was to assess the anti-inflammatory efficacy of Boswellia frereana extracts in an in vitro model of cartilage degeneration and determine its potential as a therapy for treating osteoarthritis. Cartilage degradation was induced in vitro by treating explants with 5 ng/ml interleukin1 (IL-1) and 10 ng/ml oncostatin M (OSM) over a 28-day period, in the presence or absence of 100 μg/ml B. frereana. Treatment of IL-1/OSM stimulated cartilage explants with B. frereana inhibited the breakdown of the collagenous matrix. B. frereana reduced MMP9 and MMP13 mRNA levels, inhibited MMP9 expression and activation, and significantly reduced the production of nitrite (stable end product of nitric oxide), prostaglandin E2 and cycloxygenase-2. Epi-lupeol was identified as the principal constituent of B. frereana. This is the first report on the novel anti-inflammatory properties of Boswellia frereana in an in vitro model of cartilage degradation. We have demonstrated that B. frereana prevents collagen degradation, and inhibits the production of pro-inflammatory mediators and MMPs. Due to its efficacy we propose that B. frereana should be examined further as a potential therapeutic agent for treating inflammatory symptoms associated with arthritis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	articular cartilage; Boswellia frereana; degradation; inflammation; MMPs; in vitro model
Additional Information:	Article first published online: 26 NOV 2009
Publisher:	John Wiley & Sons
ISSN:	0951-418X
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/19943... http://www.wikigenes.org/e/ref/e/1994333... http://www.mdlinx.com/orthopedics/news-a...
Last Modified:	19 Oct 2022 08:34
URI:	https://orca.cardiff.ac.uk/id/eprint/18223

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