ADAMTS4

Bondeson, Jan, Wainwright, Shane, Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661 and Hughes, Clare ORCID: https://orcid.org/0000-0003-4726-5877 2025. ADAMTS4. Rawlings, Neil D. and Auld, David S., eds. Handbook of Proteolytic Enzymes. 4th ed., London: Academic Press, pp. 1263-1273. (10.1016/B978-0-443-28849-4.00196-X)

Full text not available from this repository.

Abstract

The subject of this chapter is ADAMTS4. ADAMTS4 is a calcium-dependent metallo-endopeptidase homologous to the reprolysins. It is an ADAM protein that contains thrombospondin repeats. ADAMTS4 is an aggrecanase, cleaving the cartilage aggrecan core protein at Glu373. In addition, it cleaves other proteoglycans, including biglycan, brevican, versican, decorin, and fibromodulin, and glycoproteins such as fibronectin and transferrin. ADAMTS4 is inhibited by tissue inhibitor of metallopeptidase (TIMP)-3 (but not other TIMPs). ADAMTS4 is synthesized as a precursor and activated by a furin-like endopeptidase.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	Academic Press
ISBN:	9780443288494
Last Modified:	11 Dec 2025 13:30
URI:	https://orca.cardiff.ac.uk/id/eprint/183141

Actions (repository staff only)

Edit Item