New approaches to uncover COPD pathobiology and develop therapies

Tesfaigzi, Yohannes, Önder Yildirim, Ali, Polverino, Francesca, Conlon, Thomas M., Sidhaye, Venkataramana, Sauler, Maor, Raju, S. Vamsee, Jurkowska, Renata Z. ORCID: https://orcid.org/0000-0002-4507-2222, Chandra, Divay, Cho, Michael H., Silverman, Edwin K., Sun, Ramon C., Castaldi, Peter, Rao Tata, Purushothama, Benam, Kambez H., Antony, Linto, Lehmann, Mareike, Kosmider, Beata, Bahmed, Karim and Negasi, Zerihun H. 2026. New approaches to uncover COPD pathobiology and develop therapies. JCI Insight 11 (4) , e199693. 10.1172/jci.insight.199693

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Abstract

Chronic obstructive pulmonary disease (COPD) was the third leading cause of global mortality in 2011 but receives limited attention and research funding. This Review describes the current knowledge on COPD risk factors, including genetic and epigenetic determinants and their interactions with the microbiome and environmental exposures. Preclinical models are being refined and single-cell transcriptomic, metabolomic, and proteomic technologies are being implemented to investigate the molecular mechanisms of disease progression. Patient cohorts to define biomarkers of early disease and the latest approaches to diagnose pre-COPD are essential to accelerate the development of novel and effective therapeutic interventions and translate new findings into clinical trials. This Review is a summary of topics covered by a symposium organized by the COPD-iNET consortium, an international network of researchers who have established a platform that facilitates collaboration of this multidisciplinary group of preclinical, translational, and clinical researchers.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Additional Information:	Full author list available at DOI
Publisher:	American Society for Clinical Investigation
ISSN:	2379-3708
Date of First Compliant Deposit:	4 March 2026
Last Modified:	04 Mar 2026 14:41
URI:	https://orca.cardiff.ac.uk/id/eprint/185466

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