The role of IL-6 in rheumatoid arthritis comorbidity and implications for therapy

Monaco, Federica, Dimonte, Sandra and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2026. The role of IL-6 in rheumatoid arthritis comorbidity and implications for therapy. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1873 (4) , 120136. 10.1016/j.bbamcr.2026.120136

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Abstract

Immune-mediated inflammatory diseases (IMIDs) are complex conditions commonly associated with alterations in cytokine biology. In rheumatoid arthritis (RA), the systemic activities of cytokines, such as interleukin (IL)-6, have led to the clinical introduction of targeted medicines that greatly improve patient outcomes. However, the beneficial effects of these therapies extend beyond improvements in joint pathology and often affect a range of RA-associated comorbidities that influence a patient's quality of life. For IL-6, these include impacts on cardiovascular risk, metabolic diseases, neuropsychiatric conditions, pain, fatigue, and altered tissue homeostasis. Reviewing the involvement of classical IL-6R signalling and IL-6 trans-signalling in these processes, we will examine the mechanistic basis for these comorbidities and consider the implications for therapy in RA and related IMIDs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier BV
ISSN:	0167-4889
Date of First Compliant Deposit:	23 March 2026
Date of Acceptance:	12 March 2026
Last Modified:	23 Mar 2026 10:46
URI:	https://orca.cardiff.ac.uk/id/eprint/185934

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