Rapid and convenient thermal or microwave-assisted synthesis of substituted 2-Phenylbenzothiazoles

Weekes, Ashley Ann, Dix, Matthew C., Bagley, Mark Christopher and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2010. Rapid and convenient thermal or microwave-assisted synthesis of substituted 2-Phenylbenzothiazoles. Synthetic Communications 40 (20) , pp. 3027-3032. 10.1080/00397910903353739

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Abstract

A simple one-step method for the synthesis of biologically relevant 2-phenylbenzothiazoles has been developed, using sodium metabisulfite as an oxidant following condensation between 2-aminothiophenol and substituted benzaldehydes. Attractive features of this new method include excellent yields under both microwave-assisted or thermal conditions (it is tolerant of a variety of substituents on the phenyl ring) and simple product isolation without the need for chromatographic purification.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry Schools > Pharmacy
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	Antitumor agents, bicyclic compounds, heterocycles, microwave synthesis, 2-phenylbenzothiazoles
Publisher:	Taylor & Francis
ISSN:	0039-7911
Last Modified:	19 Oct 2022 09:02
URI:	https://orca.cardiff.ac.uk/id/eprint/19769

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