HTRA proteases: regulated proteolysis in protein quality control

Clausen, Tim, Kaiser, Markus, Huber, Robert and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2011. HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews Molecular Cell Biology 12 (3) , pp. 152-162. 10.1038/nrm3065

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Abstract

Controlled proteolysis underlies a vast diversity of protective and regulatory processes that are of key importance to cell fate. The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control. The simple combination of a classic Ser protease domain and a carboxy-terminal peptide-binding domain produces cellular factors of remarkable structural and functional plasticity that allow cells to rapidly respond to the presence of misfolded or mislocalized polypeptides.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Publisher:	Nature Publishing Group
ISSN:	1471-0072
Last Modified:	19 Oct 2022 09:48
URI:	https://orca.cardiff.ac.uk/id/eprint/22267

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