Havrylov, Serhiy, Redowicz, Maria Jolanta and Buchman, Vladimir L. ![]() |
Abstract
Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle-mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti-cancer therapies.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
Uncontrolled Keywords: | cancer cell invasion; cell adhesion; cell migration; invadopodia; malignancy; Ruk/CIN85; vesicle-mediated transport |
Publisher: | Wiley |
ISSN: | 1398-9219 |
Last Modified: | 19 Oct 2022 10:06 |
URI: | https://orca.cardiff.ac.uk/id/eprint/23247 |
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