Ras-ERK signaling in behavior: old questions and new perspectives

Fasano, Stefania ORCID: https://orcid.org/0000-0002-3696-7139 and Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706 2011. Ras-ERK signaling in behavior: old questions and new perspectives. Frontiers in Behavioral Neuroscience 5 (79) , pp. 1-6. 10.3389/fnbeh.2011.00079

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Abstract

The role of Ras–ERK signaling in behavioral plasticity is well established. Inhibition studies using the blood–brain barrier permeable drug SL327 have conclusively demonstrated that this neuronal cell signaling cascade is a crucial component of the synaptic machinery implicated in the formation of various forms of long-term memory, from spatial learning to fear and operant conditioning. However, abnormal Ras–ERK signaling has also been linked to a number of neuropsychiatric conditions, including mental retardation syndromes (“RASopathies”), drug addiction, and L-DOPA induced dyskinesia (LID). The work recently done on these brain disorders has pointed to previously underappreciated roles of Ras–ERK in specific subsets of neurons, like GABAergic interneurons of the hippocampus or the cortex, as well as in the medium spiny neurons of the striatum. Here we will highlight the open questions related to Ras–ERK signaling in these behavioral manifestations and propose crucial experiments for the future.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	Ras; ERK; neurofibromin; ERK1; drug addiction; L-DOPA induced dyskinesia; RASopathies; Ras-GRF1
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1662-5153/ (accessed 25/02/2014). This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Publisher:	Frontiers
ISSN:	1662-5153
Date of First Compliant Deposit:	30 March 2016
Last Modified:	11 May 2023 09:57
URI:	https://orca.cardiff.ac.uk/id/eprint/24319

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