Short telomeres are preferentially elongated by telomerase in human cells

Britt-Compton, Bethan, Capper, Rebecca, Rowson, Jan and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2009. Short telomeres are preferentially elongated by telomerase in human cells. FEBS Letters 583 (18) , pp. 3076-3080. 10.1016/j.febslet.2009.08.029

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Abstract

Short telomeres have been shown to be preferentially elongated in both yeast and mouse models. We examined this in human cells, by utilising cells with large allelic telomere length differentials and observing the relative rates of elongation following the expression of hTERT. We observed that short telomeres are gradually elongated in the first 26 PDs of growth, whereas the longer telomeres displayed limited elongation in this period. Telomeres coalesced at similar lengths irrespective of their length prior to the expression of hTERT. These data indicate that short telomeres are marked for gradual elongation to a cell strain specific length threshold.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	telomere, telomerase, senescence, replicative lifespan, cancer
Publisher:	Elsevier
ISSN:	0014-5793
Last Modified:	05 Nov 2022 16:12
URI:	https://orca.cardiff.ac.uk/id/eprint/25100

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