Targeting transcription factors for therapeutic benefit

Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Donev, Rossen Mintchev and Hewamana, Saman 2008. Targeting transcription factors for therapeutic benefit. Molecular Biosystems 4 (9) , pp. 909-919. 10.1039/b801920g

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Abstract

Transcription factors are a large class of biological molecules that are important for health and disease. Despite that there are challenges to targeting them therapeutically and most approaches alter their activity indirectly. Research at the chemical biology interface has led to the development of new ways of targeting transcription factors including blocking transcription factor dimerisation, targeting specific DNA sequences and DNA decoys. This review discusses these issues with a view to inspiring the development of new agents that could be useful for the treatment of cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Publisher:	Royal Society of Chemistry
ISSN:	1742-206X
Last Modified:	06 May 2023 20:21
URI:	https://orca.cardiff.ac.uk/id/eprint/25124

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