Analysis of interleukin-2 signaling using affinity precipitations and polyacrylamide gel electrophoresis

Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 and Athie-Morales, Veronica 2001. Analysis of interleukin-2 signaling using affinity precipitations and polyacrylamide gel electrophoresis. O'Neill, Luke A. J. and Bowie, Andrew, eds. Interleukin protocols, Vol. 60. Methods in Molecular Medicine, vol. 60. New Jersey: Humana Press, pp. 369-383. (10.1385/1-59259-146-9:369)

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Abstract

Interleukin-2 (IL-2) was first discovered and characterized as T-cell growth factor (1). It is responsible for the growth of T cells and thus plays an important role in the proper functioning of the immune system. IL-2 has a high affinity receptor consisting of an α-, β-, and γ-chain. The γ- chain is shared with a number of other cytokines such as IL-3 and IL-7, which also play a role in cell growth (2). The IL-2 receptor β- chain also comprises part of the receptor for IL-15.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology > QR180 Immunology R Medicine > R Medicine (General)
Publisher:	Humana Press
ISBN:	9780896037380
Related URLs:	Publisher Publisher
Last Modified:	19 Oct 2022 10:50
URI:	https://orca.cardiff.ac.uk/id/eprint/25665

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