Regulatory T cells and tumour immunity - observations in mice and men

Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 2007. Regulatory T cells and tumour immunity - observations in mice and men. Immunology 123 (2) , pp. 157-163. 10.1111/j.1365-2567.2007.02748.x

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Abstract

An enormous body of work supports a role for CD4+ CD25+ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Wiley Blackwell
ISSN:	0019-2805
Last Modified:	20 Oct 2022 07:49
URI:	https://orca.cardiff.ac.uk/id/eprint/26493

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