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Structural and biophysical determinants of ab T-cell antigen recognition

Bridgeman, John S., Sewell, Andrew K. ORCID:, Miles, John James, Price, David A. ORCID: and Cole, David K. ORCID: 2012. Structural and biophysical determinants of ab T-cell antigen recognition. Immunology 135 (1) , pp. 9-18. 10.1111/j.1365-2567.2011.03515.x

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The molecular rules that govern MHC restriction, and allow T-cells to differentiate between peptides derived from healthy cells and those from diseased cells, remain poorly understood. Here we provide an overview of the structural constraints that enable the T-cell receptor (TCR) to discriminate between self and non-self peptides, and summarize studies that have attempted to correlate the biophysical parameters of TCR/peptide–major histocompatibility complex (pMHC) binding with T-cell activation. We further review how the antigenic origin of peptide epitopes affects TCR binding parameters and the ‘quality’ of a T-cell response. Understanding the principles that govern pMHC recognition by T-cells will unlock pathways to the rational development of immunotherapeutic approaches for the treatment of infectious disease, cancer and autoimmunity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: biophysics; crystal structure; peptide-major histocompatibility complex; T-cell activation; T-cell receptor
Publisher: Wiley Blackwell
ISSN: 0019-2805
Last Modified: 10 Jun 2023 01:08

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