Prolyl oligopeptidase, inositol phosphate signalling and lithium sensitivity

Harwood, Adrian John ORCID: https://orcid.org/0000-0003-3124-5169 2011. Prolyl oligopeptidase, inositol phosphate signalling and lithium sensitivity. CNS & Neurological Disorders - Drug Targets 10 (3) , pp. 333-339. 10.2174/187152711794653779

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Abstract

Inhibition of prolyl oligopeptidase (PO) elevates inositol phosphate (IP) signalling and reduces cell sensitivity to lithium (Li+). This review discusses recent evidence that shows PO acts via the multiple inositol polyphosphate phosphatase (MIPP) to regulate gene expression. As a consequence, PO inhibition causes both a transient, rapid increase in I(1,4,5)P3 and a long-term elevation of IP signalling. This pathway is evolutionary conserved, being present in both the social amoeba Dictyostelium and human cell systems, and has potential implications for mental health.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	Bipolar mood disorder; Dictyostelium; inositol phosphate signalling; lithium; multiple inositol polyphosphate phosphatase; prolyl oligopeptidase; IMPase; LY294002; GSK-3; MIPP; ISYNA1
Publisher:	Bentham Science
ISSN:	1871-5273
Last Modified:	20 Oct 2022 07:50
URI:	https://orca.cardiff.ac.uk/id/eprint/26554

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