Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit

Moore, Catherine, Galiano, Monica, Lackenby, Angie, Abdelrahman, Tamer, Barnes, Rosemary Ann, Evans, Meirion Rhys ORCID: https://orcid.org/0000-0003-3578-1866, Fegan, Christopher, Froude, Susannah, Hastings, Mark, Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441, Litt, Emma, Price, Nicola, Salmon, Roland, Temple, Mark and Davies, Eleri 2011. Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit. International Journal of Infectious Diseases 203 (1) , pp. 18-24. 10.1093/infdis/jiq007

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Abstract

We describe the first confirmed person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus that occurred in a hematology unit in the United Kingdom. Eleven cases of (H1N1) 2009 virus infection were identified, of which, ten were related as shown by sequence analysis of the hemagglutinin and neuraminidase genes. H275Y analysis demonstrated that 8 of 10 case patients had oseltamivir-resistant virus, with 4 of 8 case patients infected by direct transmission of resistant virus. Zanamivir should be considered as first-line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influenza vaccination encouraged to further reduce the number of susceptible individuals.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QR Microbiology > QR355 Virology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Publisher:	Elsevier
ISSN:	0022-1899
Last Modified:	06 May 2024 20:30
URI:	https://orca.cardiff.ac.uk/id/eprint/26809

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