Schmidt, Julia, Neumann-Haefelin, Christoph, Altay, Tayibe, Gostick, Emma, Price, David  ORCID: https://orcid.org/0000-0001-9416-2737, Lohmann, Volker, Blum, Hubert E. and Thimme, Robert
2011.
Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency.
Journal of Virology
85
(10)
, pp. 5232-5236.
10.1128/JVI.00093-11
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Abstract
The impact of naïve precursor frequency on human virus-specific CD8+ T cell immunodominance is not well understood. Using a recently developed MHC class I tetramer enrichment protocol, we found a conserved hierarchy and >10-fold difference in naïve precursor frequencies across three HLA-A2 restricted HCV-specific epitopes. Importantly, the NS31406 epitope with the highest naïve precursor frequency in healthy donors was also the most frequently targeted epitope in a large cohort of chronically HCV-infected patients, both ex vivo and after in vitro stimulation. These results indicate for the first time that immunodominance in a human viral infection is linked to naïve precursor frequency.
| Item Type: | Article |
|---|---|
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | Q Science > QR Microbiology |
| Additional Information: | Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0022-538X/ (accessed 25/02/2014) |
| Publisher: | American Society for Microbiology |
| ISSN: | 0022-538X |
| Date of First Compliant Deposit: | 30 March 2016 |
| Last Modified: | 12 May 2023 06:51 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/27441 |
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