Therapeutic targeting of tumor–stroma interactions

Hiscox, Stephen Edward ORCID: https://orcid.org/0000-0003-0105-2702, Barrett-Lee, Peter ORCID: https://orcid.org/0000-0002-6246-7357 and Nicholson, Robert Ian 2011. Therapeutic targeting of tumor–stroma interactions. Expert Opinion on Therapeutic Targets 15 (5) , pp. 609-621. 10.1517/14728222.2011.561201

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Abstract

Introduction: Cancers exist within a complex microenvironment populated by diverse cell types within a protein-rich extracellular matrix. It is becoming increasingly apparent that molecular interactions between epithelial cells and cells in the surrounding stroma promote growth, invasion and spread of the tumor itself and thus represents a crucial underlying driving force in tumorigenesis. Areas covered: This article reviews how key interactions between tumor epithelial cells and surrounding mesenchymal and immune cells can promote tumor progression and highlights molecular elements that might represent novel therapeutic targets. Expert opinion: The tumor microenvironment is increasingly being viewed as a potential therapeutic target with a number of strategies being developed to disrupt tumor–stroma interactions, in order to delay or circumvent tumor progression. Targeting elements of the tumor microenvironment, or signaling pathways in tumor cells activated as a consequence of stromal interactions, may prove a useful therapeutic strategy to prevent tumor development and progression. However, given the tumor cells' ability to circumvent various therapeutic agents when given as monotherapy, the success of these agents is likely to be seen when used in combination with existing treatments.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	cancer-associated fibroblasts ; cancer-associated macrophages ; extracellular matrix ; integrins tumor microenvironment
Publisher:	Ashley Publications
ISSN:	1472-8222
Last Modified:	23 Jul 2024 12:42
URI:	https://orca.cardiff.ac.uk/id/eprint/28824

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