Roversi, Pietro, Johnson, Steven, Caesar, Joseph J. E., McLean, Florence, Leath, Kirstin J., Tsiftsoglou, Stefanos A., Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676, Harris, Claire Louise, Sim, Robert B. and Lea, Susan M. 2011. Structures of the rat complement regulator CrrY. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 (7) , pp. 739-743. 10.1107/S1744309111016551 |
Official URL: http://dx.doi.org/10.1107/S1744309111016551
Abstract
Complement receptor 1-related protein Y (CrrY) is an important cell-surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70° bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine Systems Immunity Research Institute (SIURI) |
Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
Uncontrolled Keywords: | complement regulator; CrrY; rat; CCP |
Publisher: | International Union of Crystallography |
ISSN: | 1744-3091 |
Last Modified: | 20 Oct 2022 08:40 |
URI: | https://orca.cardiff.ac.uk/id/eprint/29203 |
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