Positive and negative influences of regulatory T cells on tumour immunity

Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 and Simon, A. K. 2008. Positive and negative influences of regulatory T cells on tumour immunity. Oncogene 27 (45) , pp. 5886-5893. 10.1038/onc.2008.269

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Abstract

Clinicians and scientists have long questioned whether the immune system has a role in destroying cancerous tissue. Studies performed in animal models have, however, recently revealed that the immune system can, at least in principle, effectively control tumours. In parallel with these findings, a large body of evidence indicates that although the immune system has the capacity to control tumours, there are also regulatory mechanisms that subdue these responses. A major challenge of tumour immunotherapy, therefore, is to find ways of disabling these regulatory functions while restoring or priming any immune responses that are protective.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	tumour, cancer, regulatory T cells, development of regulatory T cells, Th17, Il-23
Publisher:	Nature Publishing
ISSN:	0950-9232
Last Modified:	20 Oct 2022 09:00
URI:	https://orca.cardiff.ac.uk/id/eprint/30332

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