Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment

Daw, Abdulaziz E., Kazi, Hizbullah Ashhad, Colombo, John Samuel, Rowe, Wendy Gillian, Williams, David Wynne ORCID: https://orcid.org/0000-0002-7351-5131, Waddington, Rachel J., Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 2013. Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment. Journal of Biomaterials Applications 28 (1) , pp. 144-160. 10.1177/0885328212441495

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Abstract

This study investigated the effects of combined titanium nano-/micron-scale roughness, induced by hydrogen peroxide pre-treatments, on bone marrow stromal cell responses and Porphyromonas gingivalis adherence in vitro. Untreated surfaces exhibited nano-scale features, while hydrogen peroxide treatments promoted increased nano-/micron-scale roughness. Bone marrow stromal cell attachment and proliferation were maintained with 6 h and 24 h treatments, but significantly decreased on 1-week and 4-week-treated surfaces. Bone marrow stromal cells on 6 h-4 week-treated titanium demonstrated enhanced osteogenic differentiation versus untreated surfaces. P. gingivalis adherence was significantly increased on 24 h–4 week surfaces. Results suggest that 6 h but less than 24 h treatments maintain or promote bone marrow stromal cell responses while minimizing microbial adherence, potentially enhancing titanium surface bio-activation for osseointegration.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Dentistry Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology R Medicine > R Medicine (General) R Medicine > RK Dentistry
Uncontrolled Keywords:	Bone marrow stromal cell; hydrogen peroxide; osseointegration; osteoblast; peri-implantitis; surface roughness; titanium
Publisher:	SAGE Publications
ISSN:	0885-3282
Last Modified:	07 Nov 2022 08:25
URI:	https://orca.cardiff.ac.uk/id/eprint/31912

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