Jacob, Vincent, Petreanu, Leopoldo, Wright, Nicholas Fraser, Svoboda, Karel and Fox, Kevin Dyson  ORCID: https://orcid.org/0000-0002-2563-112X
2012.
Regular spiking and intrinsic bursting pyramidal cells show orthogonal forms of experience-dependent plasticity in layer V of barrel cortex.
Neuron
73
(2)
, pp. 391-404.
10.1016/j.neuron.2011.11.034
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Abstract
Most functional plasticity studies in the cortex have focused on layers (L) II/III and IV, whereas relatively little is known of LV. Structural measurements of dendritic spines in vivo suggest some specialization among LV cell subtypes. We therefore studied experience-dependent plasticity in the barrel cortex using intracellular recordings to distinguish regular spiking (RS) and intrinsic bursting (IB) subtypes. Postsynaptic potentials and suprathreshold responses in vivo revealed a remarkable dichotomy in RS and IB cell plasticity; spared whisker potentiation occurred in IB but not RS cells while deprived whisker depression occurred in RS but not IB cells. Similar RS/IB differences were found in the LII/III to V connections in brain slices. Modeling studies showed that subthreshold changes predicted the suprathreshold changes. These studies demonstrate the major functional partition of plasticity within a single cortical layer and reveal the LII/III to LV connection as a major excitatory locus of cortical plasticity.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences Schools > Psychology |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Publisher: | Elsevier |
| ISSN: | 0896-6273 |
| Funders: | MRC, NIMH Conte Center |
| Last Modified: | 06 May 2023 17:21 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/32182 |
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