Regular spiking and intrinsic bursting pyramidal cells show orthogonal forms of experience-dependent plasticity in layer V of barrel cortex

Jacob, Vincent, Petreanu, Leopoldo, Wright, Nicholas Fraser, Svoboda, Karel and Fox, Kevin Dyson ORCID: https://orcid.org/0000-0002-2563-112X 2012. Regular spiking and intrinsic bursting pyramidal cells show orthogonal forms of experience-dependent plasticity in layer V of barrel cortex. Neuron 73 (2) , pp. 391-404. 10.1016/j.neuron.2011.11.034

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Abstract

Most functional plasticity studies in the cortex have focused on layers (L) II/III and IV, whereas relatively little is known of LV. Structural measurements of dendritic spines in vivo suggest some specialization among LV cell subtypes. We therefore studied experience-dependent plasticity in the barrel cortex using intracellular recordings to distinguish regular spiking (RS) and intrinsic bursting (IB) subtypes. Postsynaptic potentials and suprathreshold responses in vivo revealed a remarkable dichotomy in RS and IB cell plasticity; spared whisker potentiation occurred in IB but not RS cells while deprived whisker depression occurred in RS but not IB cells. Similar RS/IB differences were found in the LII/III to V connections in brain slices. Modeling studies showed that subthreshold changes predicted the suprathreshold changes. These studies demonstrate the major functional partition of plasticity within a single cortical layer and reveal the LII/III to LV connection as a major excitatory locus of cortical plasticity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Psychology
Subjects:	Q Science > QH Natural history > QH301 Biology
Publisher:	Elsevier
ISSN:	0896-6273
Funders:	MRC, NIMH Conte Center
Last Modified:	06 May 2023 17:21
URI:	https://orca.cardiff.ac.uk/id/eprint/32182

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