Behavioural analysis of transgenic mice overexpressing gamma-synuclein

Salem, Hatem 2011. Behavioural analysis of transgenic mice overexpressing gamma-synuclein. PhD Thesis, Cardiff University. Item availability restricted.

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Abstract

The alpha-synucleinopathies is a diverse group of diseases characterised by malfunctioning of alpha-synuclein protein. Parkinson’s disease is the most common of all alpha-synucleinopathies. Intracellular inclusions, like Lewy bodies and certain other abnormal structures are the pathological hallmarks of this group of neurodegenerative diseases. The main protein component of these structures is alpha-synuclien. Alpha-synuclein is a member of the synuclein family, which consists of 3 closely related proteins, alpha-, beta- and gamma-synucleins. Alpha-synuclein is more extensively studied because of its direct involvement in human diseases, while our knowledge about two other family members is very limited. Neither beta-synuclein, nor gamma-synuclein is a component of Lewy bodies and other pathological structures typical for neurodegenerative diseases.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH301 Biology
Date of First Compliant Deposit:	30 March 2016
Last Modified:	19 Mar 2016 22:56
URI:	https://orca.cardiff.ac.uk/id/eprint/32398

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