Maternal deprivation of neonatal rats produces enduring changes in dopamine function

Hall, F. S., Wilkinson, Lawrence Stephen ORCID: https://orcid.org/0000-0002-9337-6124, Humby, Trevor ORCID: https://orcid.org/0000-0002-1840-1799 and Robbins, T. W. 1999. Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse 32 (1) , pp. 37-43. 10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4

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Abstract

Isolation-rearing of weanling rats produces a syndrome of behavioral and neurochemical effects that are indicative of enhanced ventrostriatal dopamine function observed in adulthood. By contrast, maternal deprivation of neonatal rats decreases behavioral responses to dopamine agonists when tested in adults, which may indicate the opposite situation. However, in the present study it is reported that in vivo microdialysis of the nucleus accumbens (NAC) revealed enhanced release of dopamine (DA) in response to both d-amphetamine and high K+ perfusate in maternally deprived subjects. Thus, behavioral responses to d-amphetamine are diminished in maternally deprived rats despite apparent increases in presynaptic dopaminergic function in the NAC.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	dopamine; maternal deprivation; microdialysis; d-amphetamine; nucleus accumbens
Publisher:	Wiley-Blackwell
ISSN:	0887-4476
Last Modified:	21 Oct 2022 09:07
URI:	https://orca.cardiff.ac.uk/id/eprint/35354

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