Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems

Hall, F. S., Wilkinson, Lawrence Stephen ORCID: https://orcid.org/0000-0002-9337-6124, Humby, Trevor ORCID: https://orcid.org/0000-0002-1840-1799, Inglis, W., Kendall, D. A., Marsden, C. A. and Robbins, T. W. 1998. Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry and Behavior 59 (4) , pp. 859-872. 10.1016/S0091-3057(97)00510-8

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Abstract

Isolationrearing of rats produces a behavioral syndrome indicative of altered dopamine (DA) function in the nucleus accumbens (NAC). The present experiments extend these findings by investigating: (a) interactions between isolationrearing and repeated handling/testing on presynaptic DA function in the NAC using in vivo microdialysis; (b) the dose–response curve for the effects of d-amphetamine, and the responses elicited by high potassium, using in vivo microdialysis; and (c) postsynaptic function in isolates as indexed by DA receptor-linked cAMP production. Experiment 1 showed that both isolationrearing and repeated handling/testing had effects on monoamine function in the NAC. However, while both manipulations enhanced DA release evoked by d-amphetamine, only isolated rats had elevated basal DA levels. Opposite neurochemical changes were observed with respect to the serotonin metabolite 5-HIAA, isolates having lower, and repeatedly handled/tested animals having higher, extracellular levels. Experiment 2 provided evidence for enhanced d-amphetamine–evoked DA release in isolated animals, while potassium-evoked DA release was reduced. Experiment 3 provided evidence that the isolationrearing induced changes in presynaptic DA function were accompanied by postsynapticchanges. Specifically, the inhibitory influence of the D2 receptor on D1 receptor-stimulated cAMP production was attenuated in ventral striatal slices taken from isolates, suggesting a functional downregulation of D2 receptors.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Isolation rearing; Dopamine; Nucleus accumbens; In vivo microdialysis; cAMP
Publisher:	Elsevier
ISSN:	0091-3057
Last Modified:	21 Oct 2022 09:07
URI:	https://orca.cardiff.ac.uk/id/eprint/35360

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