Intra-allelic mutation at human telomeres

Britt-Compton, Bethan and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2006. Intra-allelic mutation at human telomeres. Biochemical Society Transactions 34 (4) , pp. 581-582. 10.1042/BST0340581

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Abstract

The maintenance of telomere length is important in upholding the integrity of the genome. However, it is clear from detailed observations of both telomere length and internal repeat structure that human telomeres are extremely dynamic structures and are subjected to multiple processes that create considerable heterogeneity. Genetic evidence suggests that meiotic recombination within telomeres is rare. However, there are various lines of evidence that implicate the involvement of intra-allelic processes in human telomere dynamics. In this paper, we briefly review some of this evidence and the putative mechanisms of intra-allelic telomeric mutation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	aging, cancer, intra-allelic mutation, recombination, telomerase, telomere
Publisher:	Biochemical Society
ISSN:	0300-5127
Last Modified:	21 Oct 2022 09:40
URI:	https://orca.cardiff.ac.uk/id/eprint/37289

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