PBEF/NAMPT/visfatin: a promising drug target for treating rheumatoid arthritis?

Nowell, Mari Ann, Evans, Laura Catherine and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2012. PBEF/NAMPT/visfatin: a promising drug target for treating rheumatoid arthritis? Future Medicinal Chemistry 4 (6) , pp. 751-769. 10.4155/fmc.12.34

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Abstract

NAMPT, also known as pre-B-cell colony-enhancing factor and visfatin, has been proposed to be involved in preventing apoptosis in cancer cells and, as such, has received a great deal of attention in recent years and stimulated the development to specific inhibitors for treating cancer. The role of NAMPT inhibitors as potential therapeutic agents for other diseases has not been studied extensively. Here, we describe their applicability for treating rheumatoid arthritis. We summarize current knowledge of NAMPT expression in healthy and diseased tissues, thereafter, we focus on pathological mechanisms relevant to rheumatoid arthritis that involve the NAMPT pathway and review the current status of NAMPT inhibitors being evaluated in clinical trials.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Publisher:	Future Science Ltd
ISSN:	1756-8919
Last Modified:	06 Nov 2024 22:36
URI:	https://orca.cardiff.ac.uk/id/eprint/41364

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