Enhanced stimulus-induced gamma activity in humans during propofol-induced sedation

Saxena, Neeraj ORCID: https://orcid.org/0000-0003-0913-9351, Muthukumaraswamy, Suresh Daniel ORCID: https://orcid.org/0000-0001-7042-3920, Diukova, Ana, Singh, Krish Devi ORCID: https://orcid.org/0000-0002-3094-2475, Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372 and Wise, Richard Geoffrey ORCID: https://orcid.org/0000-0003-1700-2144 2013. Enhanced stimulus-induced gamma activity in humans during propofol-induced sedation. PLoS ONE 8 (3) , e57685. 10.1371/journal.pone.0057685

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Abstract

Stimulus-induced gamma oscillations in the 30–80 Hz range have been implicated in a wide number of functions including visual processing, memory and attention. While occipital gamma-band oscillations can be pharmacologically modified in animal preparations, pharmacological modulation of stimulus-induced visual gamma oscillations has yet to be demonstrated in non-invasive human recordings. Here, in fifteen healthy humans volunteers, we probed the effects of the GABAA agonist and sedative propofol on stimulus-related gamma activity recorded with magnetoencephalography, using a simple visual grating stimulus designed to elicit gamma oscillations in the primary visual cortex. During propofol sedation as compared to the normal awake state, a significant 60% increase in stimulus-induced gamma amplitude was seen together with a 94% enhancement of stimulus-induced alpha suppression and a simultaneous reduction in the amplitude of the pattern-onset evoked response. These data demonstrate, that propofol-induced sedation is accompanied by increased stimulus-induced gamma activity providing a potential window into mechanisms of gamma-oscillation generation in humans.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Medicine Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	PLoS
ISSN:	1932-6203
Last Modified:	23 May 2024 01:07
URI:	https://orca.cardiff.ac.uk/id/eprint/44692

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