n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation

Curtis, Clare L., Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877, Flannery, C. R., Little, Chris B., Harwood, John L. ORCID: https://orcid.org/0000-0003-2377-2612 and Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661 2000. n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation. Journal of Biological Chemistry 275 (2) , pp. 721-724. 10.1074/jbc.275.2.721

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Abstract

This study describes specific molecular mechanisms by which supplementation with n-3 fatty acids (i.e. those present in fish oils) can modulate the expression and activity of degradative and inflammatory factors that cause cartilage destruction during arthritis. Our data show that incorporation of n-3 fatty acids (but not other polyunsaturated or saturated fatty acids) into articular cartilage chondrocyte membranes results in a dose-dependent reduction in: (i) the expression and activity of proteoglycan degrading enzymes (aggrecanases) and (ii) the expression of inflammation-inducible cytokines (interleukin (IL)-1α and tumor necrosis factor (TNF)-α) and cyclooxygenase (COX-2), but not the constitutively expressed cyclooxygenase COX-1. These findings provide evidence thatn-3 fatty acid supplementation can specifically affect regulatory mechanisms involved in chondrocyte gene transcription and thus further advocate a beneficial role for dietary fish oil supplementation in alleviation of several of the physiological parameters that cause and propogate arthritic disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology
Publisher:	American Society for Biochemistry and Molecular Biology
ISSN:	0021-9258
Last Modified:	24 Oct 2022 10:55
URI:	https://orca.cardiff.ac.uk/id/eprint/46403

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