Randel, Richard, Loebl, Hannah C. and Matthai, Clarence Cherian 2004. Molecular dynamics simulations of polymer translocations. Macromolecular Theory and Simulations 13 (5) , pp. 387-391. 10.1002/mats.200300019 |
Abstract
Molecular dynamics simulation studies of the translocation of charged homopolymers of length, N, driven by an electric potential gradient through a channel have been performed. We find that the translocation time, τ, displays an inverse power dependence on the temperature of the simulation τ ∼ (T − T0)−7/4, which is in very good agreement with experimental results. In addition, the dependence of τ on the driving field strength and the velocity of translocation on the polymer length N have also been obtained. The results suggest that such minimalist models are useful in modelling biological processes and that the molecular dynamics method is a suitable approach for carrying out these simulations.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Physics and Astronomy |
Subjects: | Q Science > QC Physics |
Uncontrolled Keywords: | DNA molecules; modeling; molecular dynamics; polymer translocation |
Publisher: | Wiley |
ISSN: | 1022-1344 |
Last Modified: | 04 Jun 2017 05:03 |
URI: | https://orca.cardiff.ac.uk/id/eprint/47783 |
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