Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra

Garcia-Reitboeck, Pablo, Anichtchik, Oleg, Dalley, Jeffrey W., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Tofaris, George K., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Spillantini, Maria Grazia 2013. Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. Experimental Neurology 248 , pp. 541-545. 10.1016/j.expneurol.2013.07.015

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Abstract

The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of α-synuclein in the development of a subset of dopaminergic neurons.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	α-Synuclein; Dopaminergic; Embryonic development; Parkinson's disease; Transgenic mouse
Publisher:	Elsevier
ISSN:	0014-4886
Last Modified:	12 Apr 2023 06:44
URI:	https://orca.cardiff.ac.uk/id/eprint/56909

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