Distinct effects of STAT5 activation on CD4(+) and CD8(+) T cell homeostasis: Development of CD4(+)CD25(+) regulatory T cells versus CD8(+) memory T cells

Burchill, M. A., Goetz, C. A., Prlic, M., O'Neil, J. J., Harmon, I. R., Bensinger, S. J., Turka, L. A., Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Jameson, S. C. and Farrar, M. A. 2003. Distinct effects of STAT5 activation on CD4(+) and CD8(+) T cell homeostasis: Development of CD4(+)CD25(+) regulatory T cells versus CD8(+) memory T cells. The Journal of Immunology 171 (11) , pp. 5853-5864.

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Abstract

Using transgenic mice that express a constitutively active version of STAT5b, we demonstrate that STAT5 plays a key role in governing B cell development and T cell homeostasis. STAT5 activation leads to a 10-fold increase in pro-B, but not pro-T, cells. Conversely, STAT5 signaling promotes the expansion of mature αβ T cells (6-fold increase) and γδ and NK T cells (3- to 4-fold increase), but not of mature B cells. In addition, STAT5 activation has dramatically divergent effects on CD8+ vs CD4+ T cells, leading to the selective expansion of CD8+ memory-like T cells and CD4+CD25+ regulatory T cells. These results establish that activation of STAT5 is the primary mechanism underlying both IL-7/IL-15-dependent homeostatic proliferation of naive and memory CD8+ T cells and IL-2-dependent development of CD4+CD25+ regulatory T cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	American Association of Immunologists
ISSN:	0022-1767
Last Modified:	25 Oct 2022 09:08
URI:	https://orca.cardiff.ac.uk/id/eprint/57327

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