CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia

Cardno, Alastair G., Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Guy, Carol, Jones, Lisa A., McCarthy, Geraldine, Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Murphy, Kieran C., Spurlock, Gillian, Gray, Marion, Sanders, Rebecca, Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, McGuffin, Peter, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45 (12) , pp. 1592-1596. 10.1016/s0006-3223(99)00033-5

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Abstract

BACKGROUND: Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. METHODS: Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia. RESULTS: No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores. CONCLUSIONS: This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Potassium channel; trinucleotide repeats; schizophrenia; association; negative symptoms
Publisher:	Elsevier
ISSN:	0006-3223
Last Modified:	12 Dec 2022 08:54
URI:	https://orca.cardiff.ac.uk/id/eprint/57951

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