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CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia

Cardno, Alastair G., Bowen, Timothy ORCID:, Guy, Carol, Jones, Lisa A., McCarthy, Geraldine, Williams, Nigel Melville ORCID:, Murphy, Kieran C., Spurlock, Gillian, Gray, Marion, Sanders, Rebecca, Craddock, Nicholas John ORCID:, McGuffin, Peter, Owen, Michael John ORCID: and O'Donovan, Michael Conlon ORCID: 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45 (12) , pp. 1592-1596. 10.1016/s0006-3223(99)00033-5

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BACKGROUND: Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. METHODS: Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia. RESULTS: No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores. CONCLUSIONS: This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Potassium channel; trinucleotide repeats; schizophrenia; association; negative symptoms
Publisher: Elsevier
ISSN: 0006-3223
Last Modified: 12 Dec 2022 08:54

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