No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder

Guy, Carol, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Jones, I. R., McCandless, F, McGuffin, P, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 1999. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88 (1) , pp. 57-60. 10.1002/(sici)1096-8628(19990205)88:1%3C57::aid-ajmg10%3E3.0.co;2-6

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Abstract

A recent case-control study suggested that modest enlargements of a CAG repeat in the hKCa3 potassium channel may be associated with bipolar disorder. We tried to replicate this result in a UK Caucasian sample of 203 DSM-IV bipolar I disorder patients and 206 controls group-matched for age and sex. Using the same model of analysis as the earlier study, bipolar probands did not have a higher frequency of alleles with greater than 19 repeats than controls (chi2 = 1.44, 1 df, P = 0.23). Similarly, comparison of the distributions of repeat sizes between probands and controls did not approach statistical significance (Mann-Whitney U test, P = 0.35). We conclude that our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to bipolar disorder.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Adult, Alleles, Bipolar Disorder / etiology, Bipolar Disorder / genetics*, Case Control Studies, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Potassium Channels / genetics*, Potassium Channels, Calcium Activated*, Small Conductance CalciumActivated Potassium Channels, Trinucleotide Repeats / genetics* Substances KCNN3 protein, human Potassium Channels Potassium Channels, Calcium-Activated Small-Conductance Calcium-Activated Potassium Channels
Additional Information:	Publication Types Research Support, Non-U.S. Gov't Grant Support G9309834/Medical Research Council/United Kingdom Wellcome Trust/United Kingdom Full Text Sources John Wiley & Sons, Inc. Other Literature Sources COS Scholar Universe Medical Bipolar Disorder - MedlinePlus Health Information Miscellaneous NCI CPTC Antibody Characterization Program
ISSN:	0148-7299
Last Modified:	12 Dec 2022 08:54
URI:	https://orca.cardiff.ac.uk/id/eprint/57954

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