Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder

Guy, Carol, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Daniels, J. K., Speight, G., McKeon, P., Mynett-Johnson, L., Claffey, E., McGuffin, P., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Craddock, Nicholas ORCID: https://orcid.org/0000-0003-2171-0610 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 1997. Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder. American Journal of Psychiatry 154 (8) , pp. 1146-1147.

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Abstract

OBJECTIVE: The purpose of this study was to identify the specific expanded CAG/CTG trinucleotide repeat associated with bipolar disorder. METHOD: The study employed an efficient multistage approach for using a genomic CAG/CTG screening set. RESULTS: The authors found no evidence of expanded repeats at 43 polymorphic autosomal loci and seven X chromosomal loci. Secondary screening was pursued at the only locus that contained a large allele (37 repeats) in the primary screening. No association was found between allele size and diagnostic status. CONCLUSIONS: It is highly unlikely that expansions in repeat size at any of the 50 candidate trinucleotide repeat loci examined are responsible for the association between expanded CAG/ CTG repeats and bipolar disorder. However, although the authors prioritized the repeats that were a priori most likely to be involved, the study does not reject the more general hypothesis that expanded CAG/CTG repeats are implicated in the pathogenesis of bipolar disorder.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Alleles,Bipolar Disorder/etiology,Bipolar Disorder/genetics*,DNA/genetics,Genetic Markers,Genotype,Humans,Models, Genetic,Polymerase Chain Reaction,Polymorphism, Genetic,Trinucleotide Repeats/genetics*,X Chromosome Substances Genetic Markers,DNA
Additional Information:	Publication Types Research Support, Non-U.S. Gov't Full Text Sources Silverchair Information Systems Ovid Technologies, Inc. ProQuest Other Literature Sources COS Scholar Universe Medical Bipolar Disorder - MedlinePlus Health Information
Publisher:	American Psychiatric Publishing
ISSN:	0002-953X
Last Modified:	12 Dec 2022 08:55
URI:	https://orca.cardiff.ac.uk/id/eprint/57981

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