Guy, Carol, Bowen, Timothy  ORCID: https://orcid.org/0000-0001-6050-0435, Daniels, J. K., Speight, G., McKeon, P., Mynett-Johnson, L., Claffey, E., McGuffin, P., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Craddock, Nicholas ORCID: https://orcid.org/0000-0003-2171-0610 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379
1997.
Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder.
American Journal of Psychiatry
154
(8)
, pp. 1146-1147.
|
Abstract
OBJECTIVE: The purpose of this study was to identify the specific expanded CAG/CTG trinucleotide repeat associated with bipolar disorder. METHOD: The study employed an efficient multistage approach for using a genomic CAG/CTG screening set. RESULTS: The authors found no evidence of expanded repeats at 43 polymorphic autosomal loci and seven X chromosomal loci. Secondary screening was pursued at the only locus that contained a large allele (37 repeats) in the primary screening. No association was found between allele size and diagnostic status. CONCLUSIONS: It is highly unlikely that expansions in repeat size at any of the 50 candidate trinucleotide repeat loci examined are responsible for the association between expanded CAG/ CTG repeats and bipolar disorder. However, although the authors prioritized the repeats that were a priori most likely to be involved, the study does not reject the more general hypothesis that expanded CAG/CTG repeats are implicated in the pathogenesis of bipolar disorder.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
| Subjects: | R Medicine > R Medicine (General) |
| Uncontrolled Keywords: | Alleles,Bipolar Disorder/etiology,Bipolar Disorder/genetics*,DNA/genetics,Genetic Markers,Genotype,Humans,Models, Genetic,Polymerase Chain Reaction,Polymorphism, Genetic,Trinucleotide Repeats/genetics*,X Chromosome Substances Genetic Markers,DNA |
| Additional Information: | Publication Types Research Support, Non-U.S. Gov't Full Text Sources Silverchair Information Systems Ovid Technologies, Inc. ProQuest Other Literature Sources COS Scholar Universe Medical Bipolar Disorder - MedlinePlus Health Information |
| Publisher: | American Psychiatric Publishing |
| ISSN: | 0002-953X |
| Last Modified: | 12 Dec 2022 08:55 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/57981 |
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