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Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder

Guy, Carol, Bowen, Timothy ORCID:, Daniels, J. K., Speight, G., McKeon, P., Mynett-Johnson, L., Claffey, E., McGuffin, P., Owen, Michael John ORCID:, Craddock, Nicholas ORCID: and O'Donovan, Michael Conlon ORCID: 1997. Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder. American Journal of Psychiatry 154 (8) , pp. 1146-1147.

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OBJECTIVE: The purpose of this study was to identify the specific expanded CAG/CTG trinucleotide repeat associated with bipolar disorder. METHOD: The study employed an efficient multistage approach for using a genomic CAG/CTG screening set. RESULTS: The authors found no evidence of expanded repeats at 43 polymorphic autosomal loci and seven X chromosomal loci. Secondary screening was pursued at the only locus that contained a large allele (37 repeats) in the primary screening. No association was found between allele size and diagnostic status. CONCLUSIONS: It is highly unlikely that expansions in repeat size at any of the 50 candidate trinucleotide repeat loci examined are responsible for the association between expanded CAG/ CTG repeats and bipolar disorder. However, although the authors prioritized the repeats that were a priori most likely to be involved, the study does not reject the more general hypothesis that expanded CAG/CTG repeats are implicated in the pathogenesis of bipolar disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Alleles,Bipolar Disorder/etiology,Bipolar Disorder/genetics*,DNA/genetics,Genetic Markers,Genotype,Humans,Models, Genetic,Polymerase Chain Reaction,Polymorphism, Genetic,Trinucleotide Repeats/genetics*,X Chromosome Substances Genetic Markers,DNA
Additional Information: Publication Types Research Support, Non-U.S. Gov't Full Text Sources Silverchair Information Systems Ovid Technologies, Inc. ProQuest Other Literature Sources COS Scholar Universe Medical Bipolar Disorder - MedlinePlus Health Information
Publisher: American Psychiatric Publishing
ISSN: 0002-953X
Last Modified: 12 Dec 2022 08:55

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