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Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes

McLaren, James Edward ORCID:, Rowe, Martin and Brennan, Paul ORCID: 2007. Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes. Journal of General Virology 88 (7) , pp. 1876-1886. 10.1099/vir.0.82741-0

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Since 'constitutive activation' of STAT1 was first described in Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines (LCLs), there has been controversy regarding the molecular identity of the STAT1 DNA-binding complex found in these cells. The post-translational modifications of STAT1 in LCLs have been analysed and an LMP1-induced STAT1 DNA-binding complex, different from that generated by alpha interferon (IFN) stimulation and not involving tyrosine phosphorylation, is demonstrated. STAT1 is serine-phosphorylated downstream of PI3K and MEK in LCLs and this modification restricts IFN-stimulated STAT1-DNA binding. These data suggest that EBV induces a distinct form of DNA-bound STAT1 in virus-infected cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Acetylation,B-Lymphocytes/drug effects,B-Lymphocytes/metabolism*,B-Lymphocytes/virology*,Base Sequence,Cell Line,DNA/genetics,DNA/metabolism*,Genes, Viral,Herpesvirus 4, Human/genetics,Herpesvirus 4 Human/pathogenicity*,Herpesvirus 4 Human/physiology,Humans,Interferon Type I/pharmacology,Lysine/chemistry,MAP Kinase Kinase Kinases/metabolism,Macromolecular Substances,Phosphatidylinositol,3-Kinases/metabolism,Phosphorylation,Protein Binding,Recombinant Proteins,STAT1 Transcription Factor/biosynthesis*,STAT1 Transcription Factor/chemistry,STAT1 Transcription Factor/genetics,STAT1 Transcription Factor/metabolism,Serine/chemistry,Tyrosine/chemistry,Viral Matrix Proteins/genetics,Viral Matrix Proteins/physiology Substances EBV-associated membrane antigenEpsteinBarrvirus,Interferon Type I,Macromolecular Substances,Recombinant Proteins,STAT1 Transcription Factor,STAT1 protein human ViralMatrixProteins,Tyrosine,Serine,DNA,Phosphatidylinositol 3-Kinases,MAP Kinase Kinase Kinases,Lysine
Additional Information: Full Text Sources HighWire Other Literature Sources COS Scholar Universe Molecular Biology Databases L-SERINE - HSDB L-LYSINE - HSDB L-TYROSINE - HSDB
Publisher: Society for General Microbiology
ISSN: 0022-1317
Last Modified: 25 Oct 2022 09:24

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