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Adverse features of acquired antihormone resistance and their targeting

Hiscox, Stephen Edward ORCID:, Jordan, Nicola Jane, Morgan, Liam David ORCID:, Smith, Christopher, Goddard, Lindy, Gee, Julia Margaret Wendy ORCID: and Nicholson, Robert 2009. Adverse features of acquired antihormone resistance and their targeting. Hiscox, Stephen Edward, Gee, Julia Margaret Wendy and Nicholson, Robert, eds. Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential as Targets, London: Springer, pp. 139-160. (10.1007/978-1-4020-8526-0_8)

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Endocrine therapy is the treatment of choice in hormone receptor-positive breast cancer. However, the effectiveness of these agents is limited by the development of drug resistance, ultimately leading to disease progression and patient mortality. Cell models of endocrine resistance have demonstrated a role for altered growth factor signalling in the development of an endocrine insensitive phenotype. Significantly, recent studies have revealed that the acquisition of endocrine resistance in breast cancer is also accompanied by the development of an adverse cellular phenotype, with resistant cells exhibiting altered adhesive interactions, enhanced migratory and invasive behaviour, and a capacity to induce angiogenic responses in endothelium. Since invasion and metastasis of cancer cells is a major cause of mortality in cancer patients, elucidation of molecular mechanisms underlying the adverse cellular features that accompany acquired endocrine resistance and their subsequent targeting may provide a means of limiting the progression of such tumours in vivo.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: Invasion; migration; metastasis; cell adhesion; cadherin; Src; Fak.
Publisher: Springer
ISBN: 9781402085253
Last Modified: 12 Apr 2024 06:24

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