Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles

Karaaslan, Cigdem, Kadri, Hachemi, Coban, Tulay, Suzen, Sibel and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2013. Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles. Biorganic and Medicinal Chemistry Letters 23 (9) , pp. 2671-2674. 10.1016/j.bmcl.2013.02.090

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Abstract

In this study, we report the design, synthesis and antioxidant activity of a series of substituted 2-(4-aminophenyl)-1H-indoles and 2-(methoxyphenyl)-1H-indoles. The new compounds are structurally related to the known indole-based antioxidant lead compound melatonin (MLT), and the antitumour 2-(4-aminophenyl)benzothiazole and 2-(3,4-dimethoxyphenyl)benzothiazole series. Efficient access to the target 2-phenylindoles was achieved via Fischer indole synthesis between substituted phenylhydrazines and acetophenones. 2-(4-Aminophenyl)indoles (such as the 6-fluoro analogue 3b) in particular showed potent antioxidant activity in the DPPH and superoxide radical scavenging assays (80% and 81% inhibition at 1 mM concentration of 3b, respectively), at a level comparable with the reference standard MLT (98% and 75% at 1 mM).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Publisher:	Elsevier
ISSN:	0960-894X
Last Modified:	25 Oct 2022 10:04
URI:	https://orca.cardiff.ac.uk/id/eprint/61052

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