Homology Modelling of Human E1 Ubiquitin Activating Enzyme

Brahemi, Ghali, Burger, A. M., Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 2010. Homology Modelling of Human E1 Ubiquitin Activating Enzyme. Letters in Drug Design & Discovery 7 (1) , pp. 57-62. 10.2174/157018010789869316

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Abstract

Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	ubiquitination, human E1, ubiquitin activating enzyme, homology modelling
Publisher:	PubMed Central
ISSN:	1570-1808
Last Modified:	05 Jan 2024 05:54
URI:	https://orca.cardiff.ac.uk/id/eprint/6446

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