Suri, San, Mackay, Clare E., Kelly, Michael E., Germuska, Michael ![]() |
Abstract
Background Functional magnetic resonance imaging (MRI) studies have shown that APOE ε2- and ε4-carriers have similar patterns of blood-oxygenation-level-dependent (BOLD) activation suggesting that we need to look beyond the BOLD signal to link APOE's effect on the brain to Alzheimer's disease (AD)-risk. Methods We evaluated APOE-related differences in BOLD activation in response to a memory task, cerebrovascular reactivity using a CO2-inhalation challenge (CO2-CVR), and the potential contribution of CO2-CVR to the BOLD signal. Results APOE ε4-carriers had the highest task-related hippocampal BOLD signal relative to non-carriers. The largest differences in CO2-CVR were between ε2- and ε4-carriers, with the latter having the lowest values. Genotype differences in CO2-CVR accounted for ∼70% of hippocampal BOLD differences between groups. Conclusion Because CO2-CVR gauges vascular health, the differential effect of APOE in young adults may reflect a vascular contribution to the vulnerability of ε4-carriers to late-life pathology. Studies confirming our findings are warranted.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Psychology |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Uncontrolled Keywords: | APOE gene; Alzheimer's disease; BOLD; Cerebrovascular reactivity; fMRI |
Publisher: | The Alzheimer's Association |
ISSN: | 1552-5260 |
Last Modified: | 27 Oct 2022 09:22 |
URI: | https://orca.cardiff.ac.uk/id/eprint/65397 |
Citation Data
Cited 70 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
![]() |
Edit Item |