Topical delivery of retinyl ascorbate co-drug: 6. determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes

Abdulmajed, Karim, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2005. Topical delivery of retinyl ascorbate co-drug: 6. determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes. Die Pharmazie - An International Journal of Pharmaceutical Sciences, 60 (10) , pp. 794-795.

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Abstract

The maximum effective dose of retinyl ascorbate and its potential therapeutic benefits against induced oxidative damage were assessed in vitro using cultured human epidermal keratinocytes. RA-AsA exhibited toxic effects at concentrations >6 μM. The findings indicate to the potency of RA-AsA as free radical scavenger and cell proliferation regulator.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Publisher:	Ingenta Connect
ISSN:	0031-7144
Last Modified:	27 Oct 2022 09:42
URI:	https://orca.cardiff.ac.uk/id/eprint/67449

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