Aboul-Enein, H. Y., El-Awady, M. I. and Heard, Charles Martin  ORCID: https://orcid.org/0000-0001-9703-9777
2003.
Enantiomeric resolution of some 2-arylpropionic acids using L(-)-serine-impregnated silica as stationary phase by thin layer chromatography.
Journal of Pharmaceutical and Biomedical Analysis
32
(4-5)
, pp. 1055-1059.
10.1016/S0731-7085(03)00208-5
|
Abstract
The enantiomeric resolution of certain 2-arylpropionic acids was achieved on thin silica gel plates impregnated with optically pure l-(−)-serine as chiral selector. The mobile phase enabling successful resolution of (±)-ibuproxam and (±)-ketoprofen was acetonitrile–methanol–water (16:4:0.5, v/v/v) and (16:3:0.5, v/v/v) for (±)-tiaprofenic acid. The spots were detected with iodine vapors and the detection limits were found to be different for each of the 2-arylpropionic acid, ranging between 0.25 and 0.50 μg/ml. The effect of concentration of the impregnating chiral selector, temperature and pH on resolution has been studied. The procedure was applied successfully to resolve commercial ampoules of ketoprofen dosage formulation.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Pharmacy |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Publisher: | Elsevier |
| ISSN: | 0731-7085 |
| Last Modified: | 27 Oct 2022 09:43 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/67493 |
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