Pharmaceutical applications for molecularly imprinted polymers

Allender, Christopher John, Richardson, C., Woodhouse, B., Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Brain, Keith Roger 2000. Pharmaceutical applications for molecularly imprinted polymers. International Journal of Pharmaceutics 195 (1-2) , pp. 39-43. 10.1016/S0378-5173(99)00355-5

Full text not available from this repository.

Abstract

Molecular imprinting is a means of introducing sites of specific molecular arrangement into an otherwise uniform polymeric matrix. This is achieved by formation of a pre-polymerisation complex between complementary monomers and the template molecule. Subsequent polymerisation in the presence of a crosslinker, in a porogenic environment, results in the production of a macroporous polymer capable of specific molecular recognition. This paper considers potential roles for molecularly imprinted polymers within a pharmaceutical remit. Applications including controlled release, drug monitoring devices and biological receptor mimetics are discussed. Histamine and ephedrine molecularly imprinted polymers (MIPs) were studied as potential biological receptor mimics whilst a propranolol MIP was investigated for its use as a rate attenuating selective excipient in a transdermal controlled release device. Preliminary studies concerning the preparation of a theophylline selective transcutaneous monitoring device, using a theophylline MIP, are also described.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Publisher:	Elsevier
ISSN:	0378-5173
Last Modified:	13 Feb 2024 12:51
URI:	https://orca.cardiff.ac.uk/id/eprint/67502

Citation Data

Cited 146 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item