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Pharmaceutical applications for molecularly imprinted polymers

Allender, Christopher John, Richardson, C., Woodhouse, B., Heard, Charles Martin ORCID: and Brain, Keith Roger 2000. Pharmaceutical applications for molecularly imprinted polymers. International Journal of Pharmaceutics 195 (1-2) , pp. 39-43. 10.1016/S0378-5173(99)00355-5

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Molecular imprinting is a means of introducing sites of specific molecular arrangement into an otherwise uniform polymeric matrix. This is achieved by formation of a pre-polymerisation complex between complementary monomers and the template molecule. Subsequent polymerisation in the presence of a crosslinker, in a porogenic environment, results in the production of a macroporous polymer capable of specific molecular recognition. This paper considers potential roles for molecularly imprinted polymers within a pharmaceutical remit. Applications including controlled release, drug monitoring devices and biological receptor mimetics are discussed. Histamine and ephedrine molecularly imprinted polymers (MIPs) were studied as potential biological receptor mimics whilst a propranolol MIP was investigated for its use as a rate attenuating selective excipient in a transdermal controlled release device. Preliminary studies concerning the preparation of a theophylline selective transcutaneous monitoring device, using a theophylline MIP, are also described.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Elsevier
ISSN: 0378-5173
Last Modified: 13 Feb 2024 12:51

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