Aboul-Enein, H. Y., El-Awady, M. I. and Heard, Charles Martin  ORCID: https://orcid.org/0000-0001-9703-9777
2000.
Enantiomeric separation of aminoglutethimide, acetyl aminoglutethimide, and dansyl aminoglutethimide by tlc with beta-cyclodextrin and derivatives as mobile phase additives.
Journal of Liquid Chromatography and Related Technologies
23
(17)
, pp. 2715-2726.
10.1081/JLC-100101829
|
Abstract
Racemic aminoglutethimide and acetylaminoglutethimide were resolved on a fluorescent Silica gel 60A TLC plate using 30% hydroxy trimethylpropylammonium-β-cyclodextrin with methanol (50:50v/v) as the mobile phase. Also, the resolution of the enantiomers of aminoglutethimide as dansyl derivatives were investigated on reversed phase TLC using a mobile phase consisting of a β-cyclodextrin solution (0.05 M saturated with urea), or 15% (carboxymethyl-β-cyclodextrin) solution with methanol (65:35v/v). Enantiomeric resolution was found to be highly dependent on mobile phase composition. The effect of the type and amount of organic modifier as well as the concentration of β-CD derivative, and the pH of the mobile phase on resolution were studied. Three types of maltodextrins failed to show resolution for any of the racemic compounds studied.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Pharmacy |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Publisher: | Taylor and Francis |
| ISSN: | 1082-6076 |
| Last Modified: | 27 Oct 2022 09:43 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/67503 |
Citation Data
Cited 9 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
 |
Edit Item |
Dimensions
Dimensions