Enantiomeric separation of aminoglutethimide, acetyl aminoglutethimide, and dansyl aminoglutethimide by tlc with beta-cyclodextrin and derivatives as mobile phase additives

Aboul-Enein, H. Y., El-Awady, M. I. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2000. Enantiomeric separation of aminoglutethimide, acetyl aminoglutethimide, and dansyl aminoglutethimide by tlc with beta-cyclodextrin and derivatives as mobile phase additives. Journal of Liquid Chromatography and Related Technologies 23 (17) , pp. 2715-2726. 10.1081/JLC-100101829

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Abstract

Racemic aminoglutethimide and acetylaminoglutethimide were resolved on a fluorescent Silica gel 60A TLC plate using 30% hydroxy trimethylpropylammonium-β-cyclodextrin with methanol (50:50v/v) as the mobile phase. Also, the resolution of the enantiomers of aminoglutethimide as dansyl derivatives were investigated on reversed phase TLC using a mobile phase consisting of a β-cyclodextrin solution (0.05 M saturated with urea), or 15% (carboxymethyl-β-cyclodextrin) solution with methanol (65:35v/v). Enantiomeric resolution was found to be highly dependent on mobile phase composition. The effect of the type and amount of organic modifier as well as the concentration of β-CD derivative, and the pH of the mobile phase on resolution were studied. Three types of maltodextrins failed to show resolution for any of the racemic compounds studied.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Publisher:	Taylor and Francis
ISSN:	1082-6076
Last Modified:	27 Oct 2022 09:43
URI:	https://orca.cardiff.ac.uk/id/eprint/67503

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