Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine

Osborne, C. S., Leitner, I., Hofbauer, B., Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Favre, B. and Ryder, N. S. 2006. Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine. Antimicrobial Agents and Chemotherapy 50 (6) , pp. 2234-2236. 10.1128/AAC.01600-05

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Abstract

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	American Society for Microbiology
ISSN:	0066-4804
Last Modified:	28 Oct 2022 08:36
URI:	https://orca.cardiff.ac.uk/id/eprint/71415

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