Structural characterisation and transdermal delivery studies on sugar microneedles: Experimental and finite element modelling analyses

Loizidou, Eriketi Z., Williams, Nicholas A., Barrow, David A. ORCID: https://orcid.org/0000-0003-2096-7262, Eaton, Mark J. ORCID: https://orcid.org/0000-0002-7388-6522, McCrory, John, Evans, Sam L. ORCID: https://orcid.org/0000-0003-3664-2569 and Allender, Chris J. 2015. Structural characterisation and transdermal delivery studies on sugar microneedles: Experimental and finite element modelling analyses. European Journal of Pharmaceutics and Biopharmaceutics 89 , pp. 224-231. 10.1016/j.ejpb.2014.11.023

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Abstract

Dissolving microneedles are especially attractive for transdermal drug delivery as they are associated with improved patient compliance and safety. Furthermore, microneedles made of sugars offer the added benefit of biomolecule stabilisation making them ideal candidates for delivering biological agents such as proteins, peptides and nucleic acids. In this study, we performed experimental and finite element analyses to study the mechanical properties of sugar microneedles and evaluate the effect of sugar composition on microneedle ability to penetrate and deliver drug to the skin. Results showed that microneedles made of carboxymethylcellulose/maltose are superior to those made of carboxymethylcellulose/trehalose and carboxymethylcellulose/sucrose in terms of mechanical strength and the ability to deliver drug. Buckling was predicted to be the main mode of microneedle failure and the order of buckling was positively correlated to the Young’s modulus values of the sugar constituents of each microneedle.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Engineering
Subjects:	R Medicine > RM Therapeutics. Pharmacology T Technology > TJ Mechanical engineering and machinery
Uncontrolled Keywords:	Sugar microneedles; Skin penetration; Confocal microscopy; Structural mechanics simulations; Young’s modulus; Buckling; Von Mises stress; Drug delivery
Publisher:	Elsevier
ISSN:	0939-6411
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	24 November 2014
Last Modified:	18 Nov 2024 06:30
URI:	https://orca.cardiff.ac.uk/id/eprint/72904

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