Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2015. Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction. Chemical Communications 51 (38) , pp. 8070-8073. 10.1039/C5CC00448A

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Abstract

The first copper-catalysed diastereoselective synthesis of P-chiral phosphoramidate prodrugs (ProTides) is reported. This procedure allows the synthesis of diastereomeric-enriched mixtures of ProTides. Application of this methodology to the asymmetric phosphorylation of purine and pyrimidine nucleoside analogues is presented.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology
Additional Information:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licence
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	2 April 2015
Last Modified:	06 May 2023 03:27
URI:	https://orca.cardiff.ac.uk/id/eprint/73659

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